Gene therapy pushes on, despite doubts

BAK1 Gene Variation: the doubts remain

Introduction Since Gottlieb et al. [2009] published some intriguing sequence differences between DNA obtained from abdominal aortic (AA) tissue and blood, the scientific community has been attempting to understand their findings. Dr. Gottlieb’s group was primarily interested in performing case-control association analyses in abdominal aortic aneurysm (AAA) patients. However, instead of obtainin...

Reductionist Doubts

According to reductionism, every complex phenomenon can and should be explained in terms of the simplest possible entities and mechanisms. The parts determine the whole. This approach has been an outstanding success in science, but this essay will point out ways in which it could nevertheless be giving us wrong ideas and holding back progress. For example, it may be impossible to understand key...

Doubts on the periodic health examination.

THE LOGIC behind the concept of periodic health examinations as a health maintenance procedure is impeccable. Yet many of us have feelings of doubt about their real value which are in conflict with this logic. Since logic has played only a small part in many of the successes of the scientific method, our doubts are at least respectable. It has however strongly appealed to many medical and lay m...

Doubts , Asymmetries , and Insurance ∗

This paper studies an insurance problem where agents doubt their forecasting models. Using Hansen-Sargent multiplier preferences, these doubts are represented as sets of probability distributions that are statistically hard to discriminate. Agents differ endogenously in two aspects their forecasting models and the extent of doubts surrounding these models. This heterogeneity gives rise to a new...

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